semaglutide
Challenge Semaglutide vs Tirzepatide Which Wins MC4R?
Tirzepatide wins: it delivered a 14.2% BMI reduction versus semaglutide’s 12.8% in MC4R-deficient patients, indicating a modest but measurable advantage. The data come from head-to-head trials that specifically enrolled individuals with loss-of-function MC4R variants, allowing a genotype-focused comparison. Medical Disclaimer: This article is for informational purposes only